David Lloyd DSc MBE

2024

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• Alawfi, Bader Saleem; Khan, Naveed Ahmed; Lloyd, David; Siddiqui, Ruqaiyyah 2024 Acanthamoeba keratitis: new hopes for potential interventions for a curable but often refractory disease. Expert Review of Ophthalmology, ISSN: 1746-9899 , 1746-9902; (10.1080/17469899.2024.2370881)

• Yarlett, N., Jarroll, E., Morada, M.and Lloyd, D. 2024. Protists: Eukaryotic single-celled organisms and the functioning of their organelles. Advances in Microbial Physiology
  (10.1016/bs.ampbs.2024.02.001)

 

 

2023

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• Ahortor, E., Baillie, L., Lloyd, D. and Blaxland, J. 2023. Virucidal efficacy of gaseous ozone against type 1 herpes simplex virus (hsv-1). Ozone: Science & Engineering
  (10.1080/01919512.2023.2231037)

• Williams, C. F. et al. 2023. Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz. Biochemical and Biophysical Research Communications 661, pp. 89-98.
  (10.1016/j.bbrc.2023.04.038)

• Kembro, J., Flesia, A., Nieto, P., Caliva, D., Lloyd, D., Cortassa, S. and Aon, M. 2023. A dynamically coherent pattern of rhythms that matches between distant species across the evolutionary scale. Nature Scientific Reports
  (10.1038/s41598-023-32286-0)

 

2022

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• Yarlett, N. Jarroll, E.J & Lloyd, D 2022. Protists: single-celled organisms. In (Eds.) Elsevier 

• Lloyd, D. 2022. Chronobiology of single-celled organisms. In: (Eds ) Elsevier

 

 

2021

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• Murray, D.B., Lloyd, D. Multiple rediscoveries and misconceptions; the yeast metabolic oscillator. (2021) Function 2(5), zqab039. Oxford Academic.
  https://doi.org/10.1093/function/zqab039

• Lloyd, David. 2021. Oscillations, rhythms and synchronized time bases: the key signatures of life. In A. Stefanovska and P. V. E. McClintock (eds.), Physics of Biological Oscillators, Understanding Complex Systems, pp.225-244. Springer Nature Switzerland AG.
  https://doi.org/10.1007/978-3-030-59805-1_14

• Lloyd, D., Chapman, A., Ellis, J.E.,Hillman, K., Paget, T.A., Yarlett, N., Williams, A.G.(2021). Oxygen levels are key to understanding "Anaerobic" protozoan pathogens with micro-aerophilic lifestyles. Advances in Microbial Physiology, 79, 163-240.
  https://doi.org/10.1016/bs.ampbs.2021.09.001

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2020

 

• Lloyd, D, Millet, CO, Williams, CF, Hayes, AJ, Pope, SJA, Pope, I, Borri, P, Langbein, W, Olsen, LF, Isaacs, MD & Lunding, A 2020, 'Functional imaging of a model unicell: Spironucleus vortens as an anaerobic but aerotolerant flagellated protist', Advances in Microbial Physiology. vol. 76, 41-79. (10.1016/bs.ampbs.2020.01.002)

• Gilbert, K., Hammond, K.D, Brodsky, VY & Lloyd, D. 2020. An appreciation of the prescience of Don Gilbert (1930-2011): master of the theory and experimental unraveling of biochemical and cellular oscillatory dynamics. Cell Biology International (10.1002/cbin.11341)

• Lloyd, D. 2020. Oscillations, rhythms and synchronized timekeepers: key signatures of Life. In (eds. P. McClintock and A. Stefanovska), ’Physics of Biological Oscillations’. London, Nature-Springer, pp.

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2019

 

• Lloyd, D. 2019. Saccharomyces cerevisiae: oscillatory orchestration of growth. In: Advancing Frontiers in Mycology & Mycotechnology: Basic and Applied Aspects of Fungi. Springer, pp. 181-214. (10.1007/978-981-13-9349-5_7)

• Williams, C. F. et al. 2019. Bioluminescence of Vibrio fischeri: bacteria respond quickly and sensitively to pulsed microwave electric (but not magnetic) fields. Journal of Biomedical Optics 24(5), article number: 51412. (10.1117/1.JBO.24.5.051412)
   

2018

• Kembro, JM. Cortassa, S., Lloyd, D, Sollott, SJ, & Aon, MA. 2018 Mitochondrial chaotic dynamics: redox-energetic behaviour at the edge of stability. Science Reports 8, 15422

• Groves, L. M.et al. 2018. Fluorescent functionalised naphthalimides and their Au(i)- NHC complexes for potential use in cellular bioimaging. Dalton Transactions, pp. -. (10.1039/C8DT04069A)

• Lloyd, D.et al. 2018. Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator. Journal of Biomedical Optics 24(5), article number: 51404. (10.1117/1.JBO.24.5.051404)

• Hallett, A. J.et al. 2018. Exploring the cellular uptake and localisation of phosphorescent rhenium fac-tricarbonyl metallosurfactants as a function of lipophilicity. Dalton Transactions 47(40), pp. 14241-14253. (10.1039/C8DT00669E)
   

2017

• Kurz, FK., Kembro, JM., Flesia, AG., Armoundas, AA, Cortassa, S, Miguel MA. & Lloyd D. 2017. Network dynamics: quantitative analysis of complex behaviour in metabolic, organelle, and cells; from experiments to models and back. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 9 doi: 10.1002/wsbm.1352. Epub 2016 Sep 7. Review. PMID: 27599643

• Langdon-Jones, E. E.et al. 2017. Luminescent 1,8-Naphthalimide-Derived ReI Complexes: syntheses, spectroscopy, X-ray structure and preliminary bioimaging in fission yeast cells. European Journal of Inorganic Chemistry 2017(44), pp. 5279-5287. (10.1002/ejic.201700549)

• Pope, S. J. A.et al. 2017. Anticancer, azonafide-inspired fluorescent ligands and their rhenium(I) complexes for cellular imaging. European Journal of Inorganic Chemistry 2017(3), pp. 759-766. (10.1002/ejic.201601271)
   

2016

• Lloyd, D. 2016. Biological Timekeeping: the business of a blind watchmaker. Science Progress 99(2), 1-21

• Williams, C. F.et al. 2016. What the deep sea can tell us about microwaves. Presented at: International Microwave Symposium IMS, San Francisco, California, 22-27 May 2016Microwave Symposium (IMS), 2016 IEEE MTT-S International. IEEE, (10.1109/MWSYM.2016.7540432)

• Williams, C. F.et al. 2016. The separated electric and magnetic field responses of luminescent bacteria exposed to pulsed microwave irradiation. Applied Physics Letters 109(9), article number: 93701. (10.1063/1.4961970)

• Williams, C. F.et al. 2016. The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens. Molecular and Biochemical Parasitology 206(1-2), pp. 20-28. (10.1016/j.molbiopara.2016.03.001)
   

2015

• Lloyd, D. and Williams, C. F. 2015. Avoid excessive oxygen levels in experiments with organisms, tissues and cells.. Advances in Microbial Physiology 67, pp. 293--314. (10.1016/bs.ampbs.2015.09.001)

• Stacey, O. J.et al. 2015. Water soluble, cyclometalated Pt(II)–Ln(III) conjugates towards novel bimodal imaging agents. Chemical Communications 51(61), pp. 12305-12308. (10.1039/C5CC02623G)

• Langdon-Jones, E. E.et al. 2015. Alkynyl-naphthalimide fluorophores: gold coordination chemistry and cellular imaging applications. Inorganic Chemistry 54(13), pp. 6606-6615., article number: 150618152106000. (10.1021/acs.inorgchem.5b00954)

• Lloyd, D. and Williams, C. F. 2015. New tunes from the heart. Biophysical Journal 108(8), pp. 1841-1842. (10.1016/j.bpj.2015.01.041)

• Lloyd, D. 2015. Alfred Russel Wallace: Self-educated genius and polymath. In: Luttge, U. and Beyschlag, W. eds. Progress in Botany., Vol. 76. Springer, pp. 43--74., (10.1007/978-3-319-08807-5_2)

• Lloyd, D.et al. 2015. Motility of the diplomonad fish parasite Spironucleus vortens through thixotropic solid media. Microbiology 161(1), pp. 213-218. (10.1099/mic.0.082529-0)

 

2014

• Lloyd, D. 2014. Encystment in Acanthamoeba castellanii: a review. Experimental Parasitology 145, pp. 20-27. (10.1016/j.exppara.2014.03.026)

• Lloyd, D. and Williams, C. F. 2014. Comparative biochemistry of Giardia, Hexamita and Spironucleus: Enigmatic diplomonads. Molecular and Biochemical Parasitology 197(1-2), pp. 43-49. (10.1016/j.molbiopara.2014.10.002)

• Williams, C. F.et al. 2014. Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol. Molecular and Biochemical Parasitology 196(1), pp. 45-52. (10.1016/j.molbiopara.2014.07.010)

• Langdon-Jones, E. E.et al. 2014. Fluorescent Rhenium-Naphthalimide conjugates as cellular imaging agents. Inorganic Chemistry 53(7), pp. 3788-3797. (10.1021/ic500142z)

• Lloyd, D.et al. 2014. Intracellular oxygen: similar results from two methods of measurement using Phosphorescent nanoparticles. Journal of Innovative Optical Health Sciences 7(2), article number: 1350041. (10.1142/S1793545813500417)

• Aon, M. A., Lloyd, D. and Saks, V. 2014. From physiology, genomes, systems, and self-organization to systems biology: the historical roots of a twenty-first century approach to complexity. In: Aon, M. A., Saks, V. and Schlattner, U. eds. Systems Biology of Metabolic and Signaling Networks: Energy, Mass and Information Transfer., Vol. 16. Springer Series in Biophysics Springer, pp. 3-17., (10.1007/978-3-642-38505-6_1)

• Puk, K., Guz, L. and Lloyd, D. 2014. Effects of medical plant extracts on the growth of the fish parasite Spironucleus vortens. Medycyna weterynaryjna 70(3), pp. 165-168.

 

2013

• Millet, C. O. M.et al. 2013. Mitochondria-derived organelles in the diplomonad fish parasite Spironucleus vortens. Experimental Parasitology 135(2), pp. 262-273. (10.1016/j.exppara.2013.07.003)

• Williams, C. F.et al. 2013. Diversity in mitochondrion-derived organelles of the parasitic diplomonads Spironucleus and Giardia. Trends in Parasitology 29(7), pp. 311-312. (10.1016/j.pt.2013.04.004)

• Williams, C. F.et al. 2013. Non-invasive investigation of Spironucleus vortens transmission in freshwater angelfish Pterophyllum scalare. Diseases of Aquatic Organisms 105(3), pp. 211-223. (10.3354/dao02618)

• Amariei, C.et al. 2013. The dynamics of cellular energetics during continuous yeast culture. Presented at: 35th Annual International Conference of the IEEE: Engineering in Medicine and Biology Society (EMBC), Osaka, Japan, 3-7 July 2013Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE. IEEE pp. 2708-2711., (10.1109/EMBC.2013.6610099)

• Leitsch, D.et al. 2013. Unexpected properties of NADP-dependent secondary alcohol dehydrogenase (ADH-1) in Trichomonas vaginalis and other microaerophilic parasites. Experimental Parasitology 134(3), pp. 374-380. (10.1016/j.exppara.2013.03.034)
   

2012

• Williams, C. F.et al. 2012. Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds. Veterinary Parasitology 190(1-2), pp. 62-73. (10.1016/j.vetpar.2012.05.011)

• Lloyd, D., Coogan, M. P. and Pope, S. J. 2012. Novel metal-based luminophores for biological imaging. In: Geddes, C. D. ed. Reviews in Fluorescence 2010.. Reviews in Fluorescence Vol. 7. New York: Springer, pp. 15-44., (10.1007/978-1-4419-9828-6_2)

• Williams, C. F.et al. 2012. Evaluation of two novel methods for assessing intracellular oxygen. Measurement Science and Technology 23(8), article number: 84005. (10.1088/0957-0233/23/8/084005)

• Sasidharan, K.et al. 2012. Time-Structure of the yeast metabolism in vivo. Advances in Experimental Medicine and Biology 736, pp. 359-379. (10.1007/978-1-4419-7210-1_21)

• Lloyd, D.et al. 2012. What yeast and cardiomyocytes share: ultradian oscillatory redox mechanisms of cellular coherence and survival. Integrative Biology 4(1), pp. 65-74. (10.1039/c1ib00124h)

• Systems biology of metabolic and signalling networks in biological clocks in yeast. D Lloyd & DB Murray, in Systems Biology of Metabolic and signalling Networks: Energy, Mass and Information Transfer (eds. MA Aon, V Saks & U Schattner). Springer Book, New York (2012).

• CF Williams , M  Kombrabail, K Viayalakshmi , N White,  G Krishnamoorthy,  D Lloyd. Intracellular Oxygen measurement using Quenching of Phosphorescence Lifetimes of Nanoparticles containing Polyacrylamide-embedded [Ru (dppSO3Na2)2)3]Cl2 by Pinhole Shifting Confocal Multiphoton LSM and TCSPC. Measurement Science and Technology (2012).

 

2011

• McKay, P.et al. 2011. Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design. Bioorganic & Medicinal Chemistry Letters 21(11), pp. 3335-3341. (10.1016/j.bmcl.2011.04.015)

• Millet, C. O.et al. 2011. Effect of garlic and allium-derived products on the growth and metabolism of Spironucleus vortens. Experimental Parasitology 127(2), pp. 490-499. (10.1016/j.exppara.2010.10.001)

• Stanley, B. A.et al. 2011. Thioredoxin Reductase-2 Is Essential for Keeping Low Levels of H2O2 Emission from Isolated Heart Mitochondria. The Journal of Biological Chemistry 286(38), pp. 33669-33677. (10.1074/jbc.M111.284612)

• Millet, C. O.et al. 2011. Carbohydrate and amino acid metabolism of Spironucleus vortens. Experimental Parasitology 129(1), pp. 17-26. (10.1016/j.exppara.2011.05.025)

• Thorp-Greenwood, F. L.et al. 2011. A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging. Chemical Communications 47(11), pp. 3096-3098. (10.1039/c1cc10141b)

• Williams, C. F.et al. 2011. Spironucleus species: economically-important fish pathogens and enigmatic single-celled eukaryotes. Journal of Aquaculture Research & Development(S2), article number: 2. (10.4172/2155-9546.S2-002)

• Millet, C. O.et al. 2011. In vitro culture of the diplomonad fish parasite Spironucleus vortens reveals unusually fast doubling time and atypical biphasic growth. Journal of Fish Diseases 34(1), pp. 71-73. (10.1111/j.1365-2761.2010.01213.x)

• CF Williams & D Lloyd. Composition and antimicrobial properties of sulphur-containing constituents of garlic (Allium sativum). CF Williams & D Lloyd In : Essential Oils as Natural Food additives: Composition, Applications, Antioxidant and Antimicrobial Properties. Ed. Valgimiglia , Nova Science, New York. (2011)

• Ma Aon, S Cortassa & D Lloyd. Chaos in Biochemistry and Physiology (2011) in  Mayer RA ed.Encyclopedia of Molecular and Cellular Biology and Molecular Medicine: Systems Biology. Wiley VCH Verlag & Co.KGaA.

• A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging. Thorp-Greenwood FL, Fernández-Moreira V, Millet CO, Williams CF, Cable J, Court JB, Hayes AJ, Lloyd D, Coogan MP. Chem Commun (Camb). (2011) Mar 21;47(11):3096-8. Epub 2011 Feb 11.

 

2010

• Coogan, M. P.et al. 2010. Probing intracellular oxygen by quenched phosphorescence lifetimes of nanoparticles containing polyacrylamide-embedded [Ru(dpp(SO3Na)2)3]Cl2. Photochemical and Photobiological Sciences 9(1), pp. 103-109. (10.1039/b9pp00071b)

• Fernández-Moreira, V.et al. 2010. Uptake and localisation of rhenium fac-tricarbonyl polypyridyls in fluorescent cell imaging experiments. Organic and Biomolecular Chemistry 8(17), pp. 3888-3901. (10.1039/c004610h)

• Millet, C. O., Cable, J. and Lloyd, D. 2010. The diplomonad fish parasite Spironucleus vortens produces hydrogen. Journal of Eukaryotic Microbiology 57(5), pp. 400-404. (10.1111/j.1550-7408.2010.00499.x)

• Lloyd, D., Wimpenny, J. and Venables, W. A. 2010. Alfred Russel Wallace deserves better. Journal of Biosciences 35(3), pp. 339-349. (10.1007/s12038-010-0039-x)

• New Luminophores for Biological Imaging (2010) Reviews in Fluorescence (2010) D. Lloyd, M.P. Coogan &  S. J. A. Pope (eds. C. Geddes & J.R. Lakowicz). Springer, Heidelberg.

• Novel metal-based luminophores for biological imaging (2010) Lloyd. D, Coogan M.P. & Pople SJA.Reviews in Fluorescence.

• Chaos in Biochemistry and Physiology (2010) Aon M.A., Cortassa S and Lloyd D. Encyclopedia.

• Uptake, localisation, toxicity and stability of rhenium fac-tricarbonyl bisimine pyridine derivatives as fluorophores in cell imaging studies in eukaryote cells . (2010) A. J. Amoroso, J.Cable, M.P. Coogan, J. B. Court, V. Gray, A.J. Hayes, V. Fernandez-Moreira, B. M. Kariuki, D. Lloyd, C.O. Millet, F.L.Thorp-Greenwood and C. F. Williams. Organic and Biological Chemistry.

 

2009

• Guschina, I.et al. 2009. The microaerophilic flagellate, Trichomonas vaginalis, contains unusual acyl lipids but no detectable cardiolipin. Journal of Eukaryotic Microbiology 56(1), pp. 52-57. (10.1111/j.1550-7408.2008.00365.x)

• Lloyd, D. 2009. Respiratory oscillations in yeasts. In: Maroto, M. and Monk, N. A. M. eds. Cellular Oscillatory Mechanisms.. Advances in Experimental Medicine and Biology Vol. 641. New York: Springer, pp. 118-140., (10.1007/978-0-387-09794-7_9)

• Multioscillatory behaviour in energetics and NAD(P)H dynamics in yeast. Murray DB , Machne R, Soga T, Amariei C, Lloyd D, Aon MA, Kimura C, Igarashi K, Tomita M. Systems Biol 2009.